Interactions médicamenteuses
Amitriptyline + Liothyronine
Gravité: Modérée
Amitriptyline and Liothyronine: moderate interaction.
Dernière mise à jour
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Résumé
Thyroid hormones can increase sensitivity to catecholamines and may enhance the effects of tricyclics. Reports describe increased cardiac arrhythmias and CNS stimulation. Tricyclic effect may also be accelerated when thyroid hormone is added in depression.
Ce que signifie cette interaction, en termes simples
Amitriptyline and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Liothyronine belongs to Endocrine.
Pourquoi elle survient
Increased adrenergic receptor sensitivity from thyroid hormone augments tricyclic cardiovascular and CNS effects.
Conduite à tenir
Monitor heart rate, rhythm and mental state, and keep thyroid doses stable. Consider an ECG in patients with cardiac disease.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Amitriptyline
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amitriptyline + Methylene blue Contre-indiquée
- Amitriptyline + Phenelzine Contre-indiquée
- Amitriptyline + Pimozide Contre-indiquée
- Amitriptyline + Procarbazine Contre-indiquée
- Amitriptyline + Safinamide Contre-indiquée
Autres interactions de Liothyronine
- Alogliptin-metformin + Liothyronine Modérée
- Amobarbital + Liothyronine Modérée
- Canagliflozin-metformin + Liothyronine Modérée
- Carbamazepine + Liothyronine Modérée
- Carbonyl iron + Liothyronine Modérée
- Cholestyramine + Liothyronine Modérée
Questions fréquentes
Can I take Amitriptyline with Liothyronine?
MediHelp rates the interaction as moderate. Amitriptyline and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can increase sensitivity to catecholamines and may enhance the effects of tricyclics. Reports describe increased cardiac arrhythmias and CNS stimulation. Tricyclic effect may also be accelerated when thyroid hormone is added in depression.
How serious is the interaction between Amitriptyline and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and mental state, and keep thyroid doses stable. Consider an ECG in patients with cardiac disease.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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