Drug interactions
Canagliflozin-metformin + Liothyronine
Severity: Moderate
Canagliflozin-metformin and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormones can raise blood glucose and increase insulin requirements in diabetes. Starting or increasing liothyronine may reduce the effect of canagliflozin-metformin.
What this interaction means in plain words
Canagliflozin-metformin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Liothyronine belongs to Endocrine.
Why it happens
Thyroid hormone increases hepatic glucose output, gut glucose absorption and metabolic rate, opposing antidiabetic therapy.
What to do
Monitor blood glucose when starting or changing the liothyronine dose. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
- Cholestyramine + Liothyronine Moderate
Frequently asked questions
Can I take Canagliflozin-metformin with Liothyronine?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can raise blood glucose and increase insulin requirements in diabetes. Starting or increasing liothyronine may reduce the effect of canagliflozin-metformin.
How serious is the interaction between Canagliflozin-metformin and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing the liothyronine dose. Adjust antidiabetic therapy as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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