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Interactions médicamenteuses

Carbamazepine + Isavuconazole

Gravité: Contre-indiquée

Carbamazepine and Isavuconazole: contraindicated interaction.

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Résumé

Carbamazepine strongly induces CYP3A4 and can markedly lower isavuconazole concentrations. This may lead to subtherapeutic antifungal exposure and treatment failure in invasive mold infections.

Ce que signifie cette interaction, en termes simples

Carbamazepine and Isavuconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Carbamazepine belongs to Central Nervous System; Isavuconazole belongs to Anti Fungals.

Niveau de preuve: High

Pourquoi elle survient

Induction of CYP3A4/5 (and possibly other pathways) by carbamazepine increases isavuconazole clearance.

Conduite à tenir

Do not coadminister; choose an alternative anticonvulsant or antifungal. If unavoidable, use therapeutic drug monitoring and expert advice.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Carbamazepine with Isavuconazole?

MediHelp rates the interaction as contraindicated. Carbamazepine and Isavuconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine strongly induces CYP3A4 and can markedly lower isavuconazole concentrations. This may lead to subtherapeutic antifungal exposure and treatment failure in invasive mold infections.

How serious is the interaction between Carbamazepine and Isavuconazole?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose an alternative anticonvulsant or antifungal. If unavoidable, use therapeutic drug monitoring and expert advice.

What other medicines interact with Isavuconazole?

MediHelp also lists interactions of Isavuconazole with, for example, Efavirenz, Etravirine, Ketoconazole. The full list is on the Isavuconazole page.

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