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Interactions médicamenteuses

Isavuconazole + Phenytoin

Gravité: Contre-indiquée

Isavuconazole and Phenytoin: contraindicated interaction.

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Résumé

Phenytoin is an enzyme inducer that reduces isavuconazole exposure, risking loss of antifungal efficacy. Isavuconazole may also modestly raise phenytoin levels.

Ce que signifie cette interaction, en termes simples

Isavuconazole and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isavuconazole belongs to Anti Fungals; Phenytoin belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Phenytoin induces CYP3A4/5, increasing isavuconazole metabolism.

Conduite à tenir

Avoid the combination and use a non-inducing anticonvulsant such as levetiracetam, or another antifungal. If it cannot be avoided, monitor isavuconazole and phenytoin concentrations closely.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Isavuconazole with Phenytoin?

MediHelp rates the interaction as contraindicated. Isavuconazole and Phenytoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin is an enzyme inducer that reduces isavuconazole exposure, risking loss of antifungal efficacy. Isavuconazole may also modestly raise phenytoin levels.

How serious is the interaction between Isavuconazole and Phenytoin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing anticonvulsant such as levetiracetam, or another antifungal. If it cannot be avoided, monitor isavuconazole and phenytoin concentrations closely.

What other medicines interact with Isavuconazole?

MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.

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