Référentiel des médicaments
Isavuconazole
Isavuconazole is a medicine in the class anti fungals. It is used for aspergillosis.
- Classe médicamenteuse: Anti Fungals
- Indications: aspergillosis
Dernière mise à jour Sources: EMA SmPC
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L'essentiel
- Classe médicamenteuse
- Anti Fungals
- Code ATC
- J02AC05
- Dosages courants
- 100 mg
- Interactions connues
- 15 (Contre-indiquée: 8 · Majeure: 1 · Modérée: 5 · Mineure: 1)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Fungicidal triazole that blocks ergosterol synthesis by inhibiting lanosterol 14-alpha-demethylase, causing methylated sterol precursors to accumulate and ergosterol to deplete, which weakens the fungal cell membrane.
Posologie adulte habituelle (résumé de la notice)
Invasive aspergillosis or mucormycosis (adults): loading dose 200 mg isavuconazole IV every 8 hours for the first 48 hours (six administrations); then maintenance 200 mg once daily, starting 12 to 24 hours after the last loading dose.
Grossesse et allaitement
- Grossesse
- Unsafe No human data; animal reproductive toxicity. Must not be used in pregnancy except in severe or life-threatening fungal infections where benefit outweighs risk. Not recommended in women of childbearing potential not using contraception.
- Allaitement
- Unsafe Animal data show excretion in milk; risk to infants cannot be excluded. Breast-feeding should be discontinued during treatment.
Effets indésirables signalés
- Elevated liver chemistry tests
- Nausea
- Vomiting
- Dyspnoea
- Abdominal pain
- Diarrhoea
Contre-indications
- Hypersensitivity to the active substance or excipients.
- Co-administration with ketoconazole.
- Co-administration with high-dose ritonavir (>200 mg every 12 hours).
Précautions particulières
- Hypersensitivity including anaphylaxis may occur; discontinue immediately if anaphylaxis occurs. Caution in patients hypersensitive to other azoles.
- Infusion-related reactions (hypotension, dyspnoea, dizziness, paraesthesia, nausea, headache) occur; stop the infusion if they occur.
- Severe cutaneous adverse reactions such as Stevens-Johnson syndrome have been reported with azoles; discontinue if they occur.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (15)
- Carbamazepine + Isavuconazole Contraindicated
- Efavirenz + Isavuconazole Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Isavuconazole + Ketoconazole Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Isavuconazole + Phenytoin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
- Isavuconazole + Ritonavir Contraindicated
- Isavuconazole + Sirolimus Major
- Aprepitant + Isavuconazole Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Isavuconazole used for?
Isavuconazole is a medicine in the class anti fungals. It is used for Aspergillosis, Fungal infections.
What side effects have been reported with Isavuconazole?
Elevated liver chemistry tests, Nausea, Vomiting, Dyspnoea, Abdominal pain, Diarrhoea.
Can Isavuconazole be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data; animal reproductive toxicity. Must not be used in pregnancy except in severe or life-threatening fungal infections where benefit outweighs risk. Not recommended in women of childbearing potential not using contraception. Breastfeeding: Unsafe. Animal data show excretion in milk; risk to infants cannot be excluded. Breast-feeding should be discontinued during treatment.
What does Isavuconazole interact with?
MediHelp lists 15 known interactions for Isavuconazole. Contraindicated: 8 · Major: 1 · Moderate: 5 · Minor: 1. The most serious include Carbamazepine, Efavirenz, Etravirine.
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