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Interactions médicamenteuses

Carbamazepine + Lurasidone

Gravité: Contre-indiquée

Carbamazepine and Lurasidone: contraindicated interaction.

Dernière mise à jour

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Résumé

Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of lurasidone. The result is markedly reduced lurasidone exposure and loss of antipsychotic effect.

Ce que signifie cette interaction, en termes simples

Carbamazepine and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Carbamazepine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Enzyme induction by carbamazepine increases metabolic clearance of lurasidone

Conduite à tenir

Do not co-administer; use a non-inducing alternative to carbamazepine, and allow enzyme induction to wane (several weeks) before starting lurasidone.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Carbamazepine with Lurasidone?

MediHelp rates the interaction as contraindicated. Carbamazepine and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of lurasidone. The result is markedly reduced lurasidone exposure and loss of antipsychotic effect.

How serious is the interaction between Carbamazepine and Lurasidone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-inducing alternative to carbamazepine, and allow enzyme induction to wane (several weeks) before starting lurasidone.

What other medicines interact with Lurasidone?

MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Clarithromycin. The full list is on the Lurasidone page.

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