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Interactions médicamenteuses

Apalutamide + Lurasidone

Gravité: Contre-indiquée

Apalutamide and Lurasidone: contraindicated interaction.

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Résumé

Apalutamide strongly induces CYP3A4 and markedly lowers lurasidone exposure, which can lead to loss of antipsychotic efficacy and relapse. Lurasidone labeling advises against use with strong CYP3A4 inducers.

Ce que signifie cette interaction, en termes simples

Apalutamide and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apalutamide belongs to Endocrine; Lurasidone belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Induction of CYP3A4 by apalutamide increases first-pass and systemic metabolism of lurasidone.

Conduite à tenir

Do not combine; choose an antipsychotic that is not CYP3A4-dependent or an alternative antiandrogen. Induction persists for weeks after apalutamide is stopped.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Apalutamide with Lurasidone?

MediHelp rates the interaction as contraindicated. Apalutamide and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide strongly induces CYP3A4 and markedly lowers lurasidone exposure, which can lead to loss of antipsychotic efficacy and relapse. Lurasidone labeling advises against use with strong CYP3A4 inducers.

How serious is the interaction between Apalutamide and Lurasidone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an antipsychotic that is not CYP3A4-dependent or an alternative antiandrogen. Induction persists for weeks after apalutamide is stopped.

What other medicines interact with Lurasidone?

MediHelp also lists interactions of Lurasidone with, for example, Atazanavir, Carbamazepine, Clarithromycin. The full list is on the Lurasidone page.

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