Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Darunavir + Lurasidone

Gravité: Contre-indiquée

Darunavir and Lurasidone: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and can substantially increase lurasidone concentrations. This raises the risk of dose-related adverse effects such as extrapyramidal symptoms, sedation and akathisia. Lurasidone labeling contraindicates strong CYP3A4 inhibitors.

Ce que signifie cette interaction, en termes simples

Darunavir and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Darunavir belongs to Anti Virals; Lurasidone belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Inhibition of CYP3A4-mediated first-pass and systemic metabolism of lurasidone.

Conduite à tenir

Do not coadminister; choose an antipsychotic less dependent on CYP3A4 metabolism, or use an alternative antiretroviral.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Darunavir et Lurasidone, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Darunavir with Lurasidone?

MediHelp rates the interaction as contraindicated. Darunavir and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and can substantially increase lurasidone concentrations. This raises the risk of dose-related adverse effects such as extrapyramidal symptoms, sedation and akathisia. Lurasidone labeling contraindicates strong CYP3A4 inhibitors.

How serious is the interaction between Darunavir and Lurasidone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose an antipsychotic less dependent on CYP3A4 metabolism, or use an alternative antiretroviral.

What other medicines interact with Lurasidone?

MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter