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Interactions médicamenteuses

Cobicistat + Lurasidone

Gravité: Contre-indiquée

Cobicistat and Lurasidone: contraindicated interaction.

Dernière mise à jour

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Résumé

Cobicistat is a strong CYP3A4 inhibitor that can greatly raise lurasidone exposure. This increases the risk of serious adverse effects, including extrapyramidal symptoms, sedation and QT effects, and lurasidone labeling contraindicates strong CYP3A4 inhibitors.

Ce que signifie cette interaction, en termes simples

Cobicistat and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cobicistat belongs to Miscellaneous; Lurasidone belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Cobicistat strongly inhibits CYP3A4, markedly reducing lurasidone clearance.

Conduite à tenir

Do not combine; choose an antipsychotic less dependent on CYP3A4 or an antiretroviral regimen without a booster.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cobicistat with Lurasidone?

MediHelp rates the interaction as contraindicated. Cobicistat and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A4 inhibitor that can greatly raise lurasidone exposure. This increases the risk of serious adverse effects, including extrapyramidal symptoms, sedation and QT effects, and lurasidone labeling contraindicates strong CYP3A4 inhibitors.

How serious is the interaction between Cobicistat and Lurasidone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an antipsychotic less dependent on CYP3A4 or an antiretroviral regimen without a booster.

What other medicines interact with Lurasidone?

MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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