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Interactions médicamenteuses

Carbamazepine + Selexipag

Gravité: Modérée

Carbamazepine and Selexipag: moderate interaction.

Dernière mise à jour

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Résumé

Strong enzyme inducers lower exposure to selexipag and its active metabolite, which may reduce efficacy in pulmonary arterial hypertension. Carbamazepine may have this effect through induction of its metabolism.

Ce que signifie cette interaction, en termes simples

Carbamazepine and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Carbamazepine belongs to Central Nervous System; Selexipag belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Carbamazepine induces hepatic enzymes, increasing metabolism of selexipag and its active metabolite.

Conduite à tenir

Monitor clinical response and consider titrating selexipag upward as tolerated. Reduce the dose if carbamazepine is stopped.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Carbamazepine with Selexipag?

MediHelp rates the interaction as moderate. Carbamazepine and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong enzyme inducers lower exposure to selexipag and its active metabolite, which may reduce efficacy in pulmonary arterial hypertension. Carbamazepine may have this effect through induction of its metabolism.

How serious is the interaction between Carbamazepine and Selexipag?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider titrating selexipag upward as tolerated. Reduce the dose if carbamazepine is stopped.

What other medicines interact with Carbamazepine?

MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.

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