Interactions médicamenteuses
Deferasirox + Selexipag
Gravité: Modérée
Deferasirox and Selexipag: moderate interaction.
Dernière mise à jour
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Résumé
Selexipag is converted to its active metabolite partly through CYP2C8, and deferasirox inhibits CYP2C8 moderately. Exposure to the active metabolite may increase, leading to more prostacyclin-related adverse effects such as headache, diarrhea and jaw pain.
Ce que signifie cette interaction, en termes simples
Deferasirox and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Selexipag belongs to Cardiovascular.
Pourquoi elle survient
Deferasirox inhibits CYP2C8, reducing metabolism of selexipag and its active metabolite.
Conduite à tenir
Reduce selexipag to once-daily dosing while deferasirox is used. Watch for adverse effects and return to the usual schedule if deferasirox is stopped.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Deferasirox
- Acetylsalicylic acid + Deferasirox Majeure
- Alosetron + Deferasirox Majeure
- Aluminum hydroxide + Deferasirox Majeure
- Amikacin + Deferasirox Majeure
- Argatroban + Deferasirox Majeure
- Aspirin / citric acid / sodium bicarbonate + Deferasirox Majeure
Autres interactions de Selexipag
- Gemfibrozil + Selexipag Contre-indiquée
- Abiraterone + Selexipag Modérée
- Apalutamide + Selexipag Modérée
- Carbamazepine + Selexipag Modérée
- Clopidogrel + Selexipag Modérée
- Cyclosporin + Selexipag Modérée
Questions fréquentes
Can I take Deferasirox with Selexipag?
MediHelp rates the interaction as moderate. Deferasirox and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selexipag is converted to its active metabolite partly through CYP2C8, and deferasirox inhibits CYP2C8 moderately. Exposure to the active metabolite may increase, leading to more prostacyclin-related adverse effects such as headache, diarrhea and jaw pain.
How serious is the interaction between Deferasirox and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce selexipag to once-daily dosing while deferasirox is used. Watch for adverse effects and return to the usual schedule if deferasirox is stopped.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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