Interactions médicamenteuses
Clopidogrel + Selexipag
Gravité: Modérée
Clopidogrel and Selexipag: moderate interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Clopidogrel is a strong CYP2C8 inhibitor through its glucuronide metabolite, and selexipag and its active metabolite are CYP2C8 substrates. Exposure to the active metabolite of selexipag can increase markedly, raising the risk of prostacyclin-type adverse effects such as headache, diarrhea, nausea and jaw pain.
Ce que signifie cette interaction, en termes simples
Clopidogrel and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Selexipag belongs to Cardiovascular.
Pourquoi elle survient
Clopidogrel acyl-glucuronide inhibits CYP2C8, reducing metabolism of selexipag and its active metabolite.
Conduite à tenir
Monitor for selexipag adverse effects and consider a reduced dosing frequency such as once daily if not tolerated, according to product labeling.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Clopidogrel et Selexipag, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Clopidogrel
- Clopidogrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Abrocitinib + Clopidogrel Majeure
- Acetylsalicylic acid + Clopidogrel Majeure
- Apixaban + Clopidogrel Majeure
- Aspirin + Clopidogrel Majeure
- Betrixaban + Clopidogrel Majeure
Autres interactions de Selexipag
- Gemfibrozil + Selexipag Contre-indiquée
- Abiraterone + Selexipag Modérée
- Apalutamide + Selexipag Modérée
- Carbamazepine + Selexipag Modérée
- Cyclosporin + Selexipag Modérée
- Deferasirox + Selexipag Modérée
Questions fréquentes
Can I take Clopidogrel with Selexipag?
MediHelp rates the interaction as moderate. Clopidogrel and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clopidogrel is a strong CYP2C8 inhibitor through its glucuronide metabolite, and selexipag and its active metabolite are CYP2C8 substrates. Exposure to the active metabolite of selexipag can increase markedly, raising the risk of prostacyclin-type adverse effects such as headache, diarrhea, nausea and jaw pain.
How serious is the interaction between Clopidogrel and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for selexipag adverse effects and consider a reduced dosing frequency such as once daily if not tolerated, according to product labeling.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
