Interactions médicamenteuses
Cyclosporin + Selexipag
Gravité: Modérée
Cyclosporin and Selexipag: moderate interaction.
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Résumé
Cyclosporine inhibits BCRP and other transporters involved in selexipag disposition, which may increase exposure to selexipag and its active metabolite. This could increase prostacyclin-type adverse effects such as headache, hypotension and diarrhea.
Ce que signifie cette interaction, en termes simples
Cyclosporin and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Selexipag belongs to Cardiovascular.
Pourquoi elle survient
Inhibition of ABCG2 (BCRP) and possibly other transporters or enzymes by cyclosporine raises selexipag exposure.
Conduite à tenir
Monitor for selexipag adverse effects and reduce the dose or lengthen the dosing interval if poorly tolerated.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contre-indiquée
- Aliskiren + Cyclosporin Contre-indiquée
- Bcg vaccine live + Cyclosporin Contre-indiquée
- Bosentan + Cyclosporin Contre-indiquée
- Cidofovir + Cyclosporin Contre-indiquée
- Cyclosporin + Dengue vaccine Contre-indiquée
Autres interactions de Selexipag
- Gemfibrozil + Selexipag Contre-indiquée
- Abiraterone + Selexipag Modérée
- Apalutamide + Selexipag Modérée
- Carbamazepine + Selexipag Modérée
- Clopidogrel + Selexipag Modérée
- Deferasirox + Selexipag Modérée
Questions fréquentes
Can I take Cyclosporin with Selexipag?
MediHelp rates the interaction as moderate. Cyclosporin and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits BCRP and other transporters involved in selexipag disposition, which may increase exposure to selexipag and its active metabolite. This could increase prostacyclin-type adverse effects such as headache, hypotension and diarrhea.
How serious is the interaction between Cyclosporin and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for selexipag adverse effects and reduce the dose or lengthen the dosing interval if poorly tolerated.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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