Interactions médicamenteuses
Cefazolin + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Gravité: Modérée
Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Sodium picosulfate is a prodrug that must be converted to its active laxative form by colonic bacteria. Antibiotics that suppress colonic flora may reduce this activation and lead to poorer bowel cleansing before colonoscopy. Cefazolin is given parenterally, so the effect is likely smaller than with oral antibiotics, but labeling advises caution.
Ce que signifie cette interaction, en termes simples
Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Antibiotic suppression of colonic bacteria needed to convert sodium picosulfate to its active metabolite.
Conduite à tenir
Assess bowel preparation adequacy before the procedure and consider extra preparation or rescheduling if cleansing is poor. Where possible, avoid starting antibiotics around the time of the preparation.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Cefazolin et Sodium picosulfate / magnesium oxide / anhydrous citric acid, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Cefazolin
- Amikacin + Cefazolin Modérée
- Bcg vaccine live + Cefazolin Modérée
- Cefazolin + Cholera vaccine Modérée
- Cefazolin + Dexamethasone-tobramycin Modérée
- Cefazolin + Gentamicin Modérée
- Cefazolin + Kanamycin Modérée
Questions fréquentes
Can I take Cefazolin with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that must be converted to its active laxative form by colonic bacteria. Antibiotics that suppress colonic flora may reduce this activation and lead to poorer bowel cleansing before colonoscopy. Cefazolin is given parenterally, so the effect is likely smaller than with oral antibiotics, but labeling advises caution.
How serious is the interaction between Cefazolin and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess bowel preparation adequacy before the procedure and consider extra preparation or rescheduling if cleansing is poor. Where possible, avoid starting antibiotics around the time of the preparation.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
