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Interactions médicamenteuses

Cefotetan + Heparin

Gravité: Modérée

Cefotetan and Heparin: moderate interaction.

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Résumé

Cefotetan contains an N-methylthiotetrazole side chain that can cause hypoprothrombinemia and bleeding, particularly in malnourished or elderly patients. With heparin the bleeding tendency may be increased.

Ce que signifie cette interaction, en termes simples

Cefotetan and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefotetan belongs to Anti Bacterial; Heparin belongs to Cardiovascular.

Niveau de preuve: Low

Pourquoi elle survient

Additive hemostatic impairment: cefotetan inhibits vitamin K epoxide reductase-dependent clotting factor synthesis while heparin potentiates antithrombin.

Conduite à tenir

Monitor coagulation parameters and watch for bleeding signs during co-therapy. Give vitamin K if the prothrombin time is prolonged, or select an alternative antibiotic.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cefotetan with Heparin?

MediHelp rates the interaction as moderate. Cefotetan and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefotetan contains an N-methylthiotetrazole side chain that can cause hypoprothrombinemia and bleeding, particularly in malnourished or elderly patients. With heparin the bleeding tendency may be increased.

How serious is the interaction between Cefotetan and Heparin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor coagulation parameters and watch for bleeding signs during co-therapy. Give vitamin K if the prothrombin time is prolonged, or select an alternative antibiotic.

What other medicines interact with Heparin?

MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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