Interactions médicamenteuses
Heparin + Ketorolac
Gravité: Contre-indiquée
Heparin and Ketorolac: contraindicated interaction.
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Résumé
Ketorolac inhibits platelet function and can cause GI bleeding, and heparin is an anticoagulant, so serious bleeding risk is markedly higher. Ketorolac labeling contraindicates its use in patients at risk of bleeding, including those receiving anticoagulants.
Ce que signifie cette interaction, en termes simples
Heparin and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Heparin belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Pourquoi elle survient
Additive hemostatic impairment from NSAID platelet inhibition and heparin-mediated antithrombin potentiation.
Conduite à tenir
Avoid ketorolac in patients on therapeutic heparin and use a non-NSAID analgesic; if exposure occurs, monitor for bleeding and hemoglobin and aPTT.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Ketorolac
- Aceclofenac + Ketorolac Contre-indiquée
- Acemetacin + Ketorolac Contre-indiquée
- Acetylsalicylic acid + Ketorolac Contre-indiquée
- Apixaban + Ketorolac Contre-indiquée
- Argatroban + Ketorolac Contre-indiquée
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contre-indiquée
Autres interactions de Heparin
- Defibrotide + Heparin Contre-indiquée
- Heparin + Oritavancin Contre-indiquée
- Acemetacin + Heparin Majeure
- Acetylsalicylic acid + Heparin Majeure
- Alteplase + Heparin Majeure
- Andexanet alfa + Heparin Majeure
Questions fréquentes
Can I take Heparin with Ketorolac?
MediHelp rates the interaction as contraindicated. Heparin and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac inhibits platelet function and can cause GI bleeding, and heparin is an anticoagulant, so serious bleeding risk is markedly higher. Ketorolac labeling contraindicates its use in patients at risk of bleeding, including those receiving anticoagulants.
How serious is the interaction between Heparin and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients on therapeutic heparin and use a non-NSAID analgesic; if exposure occurs, monitor for bleeding and hemoglobin and aPTT.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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