Interactions médicamenteuses
Ceftazidime + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Gravité: Modérée
Ceftazidime and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Dernière mise à jour
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Résumé
Sodium picosulfate is a prodrug activated by colonic bacteria, so antibiotics that disrupt colonic flora may reduce its laxative effect. Parenteral ceftazidime reaches the colon less than oral antibiotics, but poor bowel cleansing before colonoscopy is possible.
Ce que signifie cette interaction, en termes simples
Ceftazidime and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Antibiotic suppression of colonic bacteria reduces conversion of picosulfate to its active metabolite.
Conduite à tenir
Assess bowel preparation adequacy and consider additional or alternative cleansing if the preparation seems inadequate. Where possible, avoid starting antibiotics during the preparation period.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Ceftazidime
- Amikacin + Ceftazidime Modérée
- Ceftazidime + Cholera vaccine Modérée
- Ceftazidime + Dexamethasone-tobramycin Modérée
- Ceftazidime + Gentamicin Modérée
- Ceftazidime + Kanamycin Modérée
- Ceftazidime + Microbiota Modérée
Questions fréquentes
Can I take Ceftazidime with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Ceftazidime and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug activated by colonic bacteria, so antibiotics that disrupt colonic flora may reduce its laxative effect. Parenteral ceftazidime reaches the colon less than oral antibiotics, but poor bowel cleansing before colonoscopy is possible.
How serious is the interaction between Ceftazidime and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess bowel preparation adequacy and consider additional or alternative cleansing if the preparation seems inadequate. Where possible, avoid starting antibiotics during the preparation period.
What other medicines interact with Ceftazidime?
MediHelp also lists interactions of Ceftazidime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Ceftazidime page.
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