Drug interactions
Ceftazidime + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Ceftazidime and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium picosulfate is a prodrug activated by colonic bacteria, so antibiotics that disrupt colonic flora may reduce its laxative effect. Parenteral ceftazidime reaches the colon less than oral antibiotics, but poor bowel cleansing before colonoscopy is possible.
What this interaction means in plain words
Ceftazidime and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic suppression of colonic bacteria reduces conversion of picosulfate to its active metabolite.
What to do
Assess bowel preparation adequacy and consider additional or alternative cleansing if the preparation seems inadequate. Where possible, avoid starting antibiotics during the preparation period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceftazidime
- Amikacin + Ceftazidime Moderate
- Ceftazidime + Cholera vaccine Moderate
- Ceftazidime + Dexamethasone-tobramycin Moderate
- Ceftazidime + Gentamicin Moderate
- Ceftazidime + Kanamycin Moderate
- Ceftazidime + Microbiota Moderate
Frequently asked questions
Can I take Ceftazidime with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Ceftazidime and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug activated by colonic bacteria, so antibiotics that disrupt colonic flora may reduce its laxative effect. Parenteral ceftazidime reaches the colon less than oral antibiotics, but poor bowel cleansing before colonoscopy is possible.
How serious is the interaction between Ceftazidime and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess bowel preparation adequacy and consider additional or alternative cleansing if the preparation seems inadequate. Where possible, avoid starting antibiotics during the preparation period.
What other medicines interact with Ceftazidime?
MediHelp also lists interactions of Ceftazidime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Ceftazidime page.
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