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Interactions médicamenteuses

Celecoxib + Ketorolac

Gravité: Contre-indiquée

Celecoxib and Ketorolac: contraindicated interaction.

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Résumé

Ketorolac is contraindicated with other NSAIDs, and celecoxib adds cyclo-oxygenase inhibition on top of ketorolac's. Gastrointestinal bleeding, renal injury and cardiovascular events are more likely without additional analgesic benefit.

Ce que signifie cette interaction, en termes simples

Celecoxib and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Celecoxib belongs to Musculoskeletal; Ketorolac belongs to Musculoskeletal.

Niveau de preuve: High

Pourquoi elle survient

Additive COX inhibition causing gastrointestinal, renal and platelet effects

Conduite à tenir

Do not use together; use one NSAID only, or add paracetamol or an opioid for additional analgesia.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Celecoxib with Ketorolac?

MediHelp rates the interaction as contraindicated. Celecoxib and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac is contraindicated with other NSAIDs, and celecoxib adds cyclo-oxygenase inhibition on top of ketorolac's. Gastrointestinal bleeding, renal injury and cardiovascular events are more likely without additional analgesic benefit.

How serious is the interaction between Celecoxib and Ketorolac?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; use one NSAID only, or add paracetamol or an opioid for additional analgesia.

What other medicines interact with Ketorolac?

MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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