Drug interactions
Chloroquine + Cisapride
Severity: Contraindicated
Chloroquine and Cisapride: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Used together they raise the risk of torsades de pointes and sudden cardiac death. Cisapride is already restricted because of this risk.
What this interaction means in plain words
Chloroquine and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Chloroquine belongs to Anti Parasitic; Cisapride belongs to Gastrointestinal Tract.
Why it happens
Additive blockade of cardiac hERG potassium channels causing delayed repolarization and QT prolongation.
What to do
Avoid the combination; use a non-QT-prolonging prokinetic or antimalarial alternative. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
- Cisapride + Clarithromycin Contraindicated
Other interactions of Chloroquine
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
- Chloroquine + Quinidine Contraindicated
Frequently asked questions
Can I take Chloroquine with Cisapride?
MediHelp rates the interaction as contraindicated. Chloroquine and Cisapride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval. Used together they raise the risk of torsades de pointes and sudden cardiac death. Cisapride is already restricted because of this risk.
How serious is the interaction between Chloroquine and Cisapride?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-QT-prolonging prokinetic or antimalarial alternative. If unavoidable, obtain a baseline ECG and correct potassium and magnesium before and during therapy.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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