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Interactions médicamenteuses

Cholestyramine + Vitamin k1

Gravité: Modérée

Cholestyramine and Vitamin k1: moderate interaction.

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Résumé

Long-term cholestyramine can reduce vitamin K absorption and lead to hypoprothrombinemia and increased bleeding tendency. The risk is greater in patients on anticoagulants or with malnutrition or liver disease.

Ce que signifie cette interaction, en termes simples

Cholestyramine and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cholestyramine belongs to Cardiovascular; Vitamin k1 belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Cholestyramine binds bile acids and impairs micelle formation, reducing absorption of fat-soluble vitamin K.

Conduite à tenir

Monitor INR or prothrombin time during prolonged cholestyramine therapy and supplement vitamin K if prolonged. Give vitamin K separately from the resin.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cholestyramine with Vitamin k1?

MediHelp rates the interaction as moderate. Cholestyramine and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-term cholestyramine can reduce vitamin K absorption and lead to hypoprothrombinemia and increased bleeding tendency. The risk is greater in patients on anticoagulants or with malnutrition or liver disease.

How serious is the interaction between Cholestyramine and Vitamin k1?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR or prothrombin time during prolonged cholestyramine therapy and supplement vitamin K if prolonged. Give vitamin K separately from the resin.

What other medicines interact with Cholestyramine?

MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.

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