Drug interactions
Cholestyramine + Vitamin k1
Severity: Moderate
Cholestyramine and Vitamin k1: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term cholestyramine can reduce vitamin K absorption and lead to hypoprothrombinemia and increased bleeding tendency. The risk is greater in patients on anticoagulants or with malnutrition or liver disease.
What this interaction means in plain words
Cholestyramine and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Vitamin k1 belongs to Cardiovascular.
Why it happens
Cholestyramine binds bile acids and impairs micelle formation, reducing absorption of fat-soluble vitamin K.
What to do
Monitor INR or prothrombin time during prolonged cholestyramine therapy and supplement vitamin K if prolonged. Give vitamin K separately from the resin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cholestyramine and Vitamin k1, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Cholestyramine
Other interactions of Vitamin k1
- Vitamin k1 + Warfarin Major
- Colestipol + Vitamin k1 Moderate
- Ketorolac intranasal + Vitamin k1 Moderate
- Mineral oil + Vitamin k1 Moderate
- Orlistat + Vitamin k1 Moderate
- Aescin + Vitamin k1 Minor
Frequently asked questions
Can I take Cholestyramine with Vitamin k1?
MediHelp rates the interaction as moderate. Cholestyramine and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-term cholestyramine can reduce vitamin K absorption and lead to hypoprothrombinemia and increased bleeding tendency. The risk is greater in patients on anticoagulants or with malnutrition or liver disease.
How serious is the interaction between Cholestyramine and Vitamin k1?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR or prothrombin time during prolonged cholestyramine therapy and supplement vitamin K if prolonged. Give vitamin K separately from the resin.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
