Interactions médicamenteuses
Cilastatin-imipenem + Microbiota
Gravité: Modérée
Cilastatin-imipenem and Microbiota: moderate interaction.
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Résumé
Oral microbiota spore products require live bacteria to colonize the gut. Imipenem is a broad-spectrum carbapenem that may kill the administered organisms and reduce efficacy. Careful timing after antibiotic therapy is needed.
Ce que signifie cette interaction, en termes simples
Cilastatin-imipenem and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Antibacterial activity against the live bacterial content impairs engraftment.
Conduite à tenir
Finish antibiotic therapy and observe the labeled washout interval before administering the microbiota product. Avoid concurrent systemic antibiotics where possible.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cilastatin-imipenem
Questions fréquentes
Can I take Cilastatin-imipenem with Microbiota?
MediHelp rates the interaction as moderate. Cilastatin-imipenem and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral microbiota spore products require live bacteria to colonize the gut. Imipenem is a broad-spectrum carbapenem that may kill the administered organisms and reduce efficacy. Careful timing after antibiotic therapy is needed.
How serious is the interaction between Cilastatin-imipenem and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Finish antibiotic therapy and observe the labeled washout interval before administering the microbiota product. Avoid concurrent systemic antibiotics where possible.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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