Drug interactions
Cilastatin-imipenem + Microbiota
Severity: Moderate
Cilastatin-imipenem and Microbiota: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral microbiota spore products require live bacteria to colonize the gut. Imipenem is a broad-spectrum carbapenem that may kill the administered organisms and reduce efficacy. Careful timing after antibiotic therapy is needed.
What this interaction means in plain words
Cilastatin-imipenem and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live bacterial content impairs engraftment.
What to do
Finish antibiotic therapy and observe the labeled washout interval before administering the microbiota product. Avoid concurrent systemic antibiotics where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilastatin-imipenem
Frequently asked questions
Can I take Cilastatin-imipenem with Microbiota?
MediHelp rates the interaction as moderate. Cilastatin-imipenem and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral microbiota spore products require live bacteria to colonize the gut. Imipenem is a broad-spectrum carbapenem that may kill the administered organisms and reduce efficacy. Careful timing after antibiotic therapy is needed.
How serious is the interaction between Cilastatin-imipenem and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Finish antibiotic therapy and observe the labeled washout interval before administering the microbiota product. Avoid concurrent systemic antibiotics where possible.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Valproic acid. The full list is on the Cilastatin-imipenem page.
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