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Interactions médicamenteuses

Cilostazol + Vonoprazan

Gravité: Modérée

Cilostazol and Vonoprazan: moderate interaction.

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Résumé

Vonoprazan may increase cilostazol exposure through effects on CYP2C19 and CYP3A4, which could increase cilostazol adverse effects such as headache and tachycardia.

Ce que signifie cette interaction, en termes simples

Cilostazol and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cilostazol belongs to Cardiovascular; Vonoprazan belongs to Gastrointestinal Tract.

Niveau de preuve: Low

Pourquoi elle survient

Vonoprazan may inhibit CYP2C19 and CYP3A4 metabolism of cilostazol.

Conduite à tenir

Consider reducing cilostazol to 50 mg twice daily during co-administration. Monitor heart rate and tolerability.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cilostazol with Vonoprazan?

MediHelp rates the interaction as moderate. Cilostazol and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan may increase cilostazol exposure through effects on CYP2C19 and CYP3A4, which could increase cilostazol adverse effects such as headache and tachycardia.

How serious is the interaction between Cilostazol and Vonoprazan?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing cilostazol to 50 mg twice daily during co-administration. Monitor heart rate and tolerability.

What other medicines interact with Cilostazol?

MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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