Drug interactions
Cilostazol + Vonoprazan
Severity: Moderate
Cilostazol and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan may increase cilostazol exposure through effects on CYP2C19 and CYP3A4, which could increase cilostazol adverse effects such as headache and tachycardia.
What this interaction means in plain words
Cilostazol and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Vonoprazan may inhibit CYP2C19 and CYP3A4 metabolism of cilostazol.
What to do
Consider reducing cilostazol to 50 mg twice daily during co-administration. Monitor heart rate and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Cilostazol with Vonoprazan?
MediHelp rates the interaction as moderate. Cilostazol and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan may increase cilostazol exposure through effects on CYP2C19 and CYP3A4, which could increase cilostazol adverse effects such as headache and tachycardia.
How serious is the interaction between Cilostazol and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing cilostazol to 50 mg twice daily during co-administration. Monitor heart rate and tolerability.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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