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Interactions médicamenteuses

Ciprofloxacin + Macimorelin

Gravité: Majeure

Ciprofloxacin and Macimorelin: major interaction.

Dernière mise à jour Sources: UK SmPC

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Résumé

Macimorelin causes a small QT prolongation, and ciprofloxacin also prolongs QT, so the combination may increase arrhythmia risk during the growth hormone stimulation test. The test is single-dose, which limits exposure.

Ce que signifie cette interaction, en termes simples

Ciprofloxacin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Ciprofloxacin belongs to Anti Bacterial; Macimorelin belongs to Endocrine.

Niveau de preuve: Low

Pourquoi elle survient

Additive pharmacodynamic QT prolongation.

Conduite à tenir

Postpone the macimorelin test until ciprofloxacin has been stopped and cleared, or use another diagnostic option. If unavoidable, obtain an ECG and correct electrolytes.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Ciprofloxacin with Macimorelin?

MediHelp rates the interaction as major. Ciprofloxacin and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes a small QT prolongation, and ciprofloxacin also prolongs QT, so the combination may increase arrhythmia risk during the growth hormone stimulation test. The test is single-dose, which limits exposure.

How serious is the interaction between Ciprofloxacin and Macimorelin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpone the macimorelin test until ciprofloxacin has been stopped and cleared, or use another diagnostic option. If unavoidable, obtain an ECG and correct electrolytes.

What other medicines interact with Ciprofloxacin?

MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.

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