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Interactions médicamenteuses

Ciprofloxacin + Thioridazine

Gravité: Contre-indiquée

Ciprofloxacin and Thioridazine: contraindicated interaction.

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Résumé

Thioridazine causes marked QT prolongation and is contraindicated with other drugs that prolong the QT interval. Ciprofloxacin adds to this risk of torsades de pointes and sudden death.

Ce que signifie cette interaction, en termes simples

Ciprofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ciprofloxacin belongs to Anti Bacterial; Thioridazine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive inhibition of cardiac potassium channels causing delayed repolarization.

Conduite à tenir

Avoid the combination and choose an antibiotic without QT effects. If antipsychotic therapy must continue, use a non-QT-prolonging agent for the infection.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ciprofloxacin with Thioridazine?

MediHelp rates the interaction as contraindicated. Ciprofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked QT prolongation and is contraindicated with other drugs that prolong the QT interval. Ciprofloxacin adds to this risk of torsades de pointes and sudden death.

How serious is the interaction between Ciprofloxacin and Thioridazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antibiotic without QT effects. If antipsychotic therapy must continue, use a non-QT-prolonging agent for the infection.

What other medicines interact with Ciprofloxacin?

MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Tizanidine. The full list is on the Ciprofloxacin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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