Interactions médicamenteuses
Ciprofloxacin + Fezolinetant
Gravité: Contre-indiquée
Ciprofloxacin and Fezolinetant: contraindicated interaction.
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Résumé
Ciprofloxacin is a moderate CYP1A2 inhibitor, and fezolinetant is mainly cleared by CYP1A2. Coadministration raises fezolinetant exposure and may increase risk of adverse effects including liver enzyme elevations.
Ce que signifie cette interaction, en termes simples
Ciprofloxacin and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ciprofloxacin belongs to Anti Bacterial; Fezolinetant belongs to Endocrine.
Pourquoi elle survient
Inhibition of CYP1A2-mediated metabolism of fezolinetant by ciprofloxacin.
Conduite à tenir
Do not use together as per fezolinetant labeling. Choose a non-CYP1A2-inhibiting antibiotic or hold fezolinetant during the short course.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Ciprofloxacin
- Agomelatine + Ciprofloxacin Contre-indiquée
- Ciprofloxacin + Thioridazine Contre-indiquée
- Ciprofloxacin + Tizanidine Contre-indiquée
- Ciprofloxacin + Vandetanib Contre-indiquée
- Alosetron + Ciprofloxacin Majeure
- Aluminum hydroxide + Ciprofloxacin Majeure
Autres interactions de Fezolinetant
- Cimetidine + Fezolinetant Contre-indiquée
- Desogestrel-ethinyl estradiol + Fezolinetant Contre-indiquée
- Estradiol + Fezolinetant Contre-indiquée
- Ethinyl estradiol-drospirenone + Fezolinetant Contre-indiquée
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contre-indiquée
- Ethinyl estradiol-norgestimate + Fezolinetant Contre-indiquée
Questions fréquentes
Can I take Ciprofloxacin with Fezolinetant?
MediHelp rates the interaction as contraindicated. Ciprofloxacin and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ciprofloxacin is a moderate CYP1A2 inhibitor, and fezolinetant is mainly cleared by CYP1A2. Coadministration raises fezolinetant exposure and may increase risk of adverse effects including liver enzyme elevations.
How serious is the interaction between Ciprofloxacin and Fezolinetant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together as per fezolinetant labeling. Choose a non-CYP1A2-inhibiting antibiotic or hold fezolinetant during the short course.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Thioridazine, Tizanidine. The full list is on the Ciprofloxacin page.
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