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Interactions médicamenteuses

Ciprofloxacin + Tizanidine

Gravité: Contre-indiquée

Ciprofloxacin and Tizanidine: contraindicated interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Ciprofloxacin markedly increases tizanidine exposure, with studies showing roughly a ten-fold rise in peak concentration and about a 10-fold rise in AUC. This can cause severe hypotension, bradycardia, marked sedation and dizziness. The combination is contraindicated in tizanidine labeling.

Ce que signifie cette interaction, en termes simples

Ciprofloxacin and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ciprofloxacin belongs to Anti Bacterial; Tizanidine belongs to Musculoskeletal.

Niveau de preuve: High

Pourquoi elle survient

Ciprofloxacin is a potent CYP1A2 inhibitor and blocks the main metabolic pathway of tizanidine, greatly increasing its systemic exposure.

Conduite à tenir

Do not co-administer. Choose an antibiotic that does not inhibit CYP1A2, or temporarily replace tizanidine with another antispasticity agent such as baclofen.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Ciprofloxacin with Tizanidine?

MediHelp rates the interaction as contraindicated. Ciprofloxacin and Tizanidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ciprofloxacin markedly increases tizanidine exposure, with studies showing roughly a ten-fold rise in peak concentration and about a 10-fold rise in AUC. This can cause severe hypotension, bradycardia, marked sedation and dizziness. The combination is contraindicated in tizanidine labeling.

How serious is the interaction between Ciprofloxacin and Tizanidine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Choose an antibiotic that does not inhibit CYP1A2, or temporarily replace tizanidine with another antispasticity agent such as baclofen.

What other medicines interact with Tizanidine?

MediHelp also lists interactions of Tizanidine with, for example, Fluvoxamine, Pefloxacin, Pipemidic acid. The full list is on the Tizanidine page.

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