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Interactions médicamenteuses

Clarithromycin + Dabrafenib

Gravité: Majeure

Clarithromycin and Dabrafenib: major interaction.

Dernière mise à jour

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Résumé

Clarithromycin may increase dabrafenib plasma concentrations, raising the risk of adverse effects such as pyrexia, rash and QT prolongation. Dabrafenib itself is a CYP3A4 inducer, which can also lower clarithromycin exposure.

Ce que signifie cette interaction, en termes simples

Clarithromycin and Dabrafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clarithromycin belongs to Anti Bacterial; Dabrafenib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Clarithromycin inhibits CYP3A4 and P-glycoprotein, reducing the metabolism of dabrafenib, which is a CYP3A4 and CYP2C8 substrate.

Conduite à tenir

Prefer an alternative antibiotic such as azithromycin. If it cannot be avoided, monitor closely for dabrafenib toxicity and QTc, and reduce the dabrafenib dose if adverse effects emerge.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clarithromycin with Dabrafenib?

MediHelp rates the interaction as major. Clarithromycin and Dabrafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin may increase dabrafenib plasma concentrations, raising the risk of adverse effects such as pyrexia, rash and QT prolongation. Dabrafenib itself is a CYP3A4 inducer, which can also lower clarithromycin exposure.

How serious is the interaction between Clarithromycin and Dabrafenib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic such as azithromycin. If it cannot be avoided, monitor closely for dabrafenib toxicity and QTc, and reduce the dabrafenib dose if adverse effects emerge.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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