Interactions médicamenteuses
Cariprazine + Dabrafenib
Gravité: Majeure
Cariprazine and Dabrafenib: major interaction.
Dernière mise à jour
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Résumé
Dabrafenib is a CYP3A4 inducer that may lower concentrations of cariprazine and its active metabolites, which are cleared by CYP3A4. The size of the effect is not well characterised, and loss of antipsychotic efficacy is possible.
Ce que signifie cette interaction, en termes simples
Cariprazine and Dabrafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Dabrafenib belongs to Oncology.
Pourquoi elle survient
Dabrafenib induces CYP3A4, which may increase clearance of cariprazine and its active metabolites.
Conduite à tenir
Avoid the combination where possible, as labeling advises against strong CYP3A4 inducers. If it is unavoidable, monitor for loss of psychiatric control and consider dose adjustment.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cariprazine
- Alfentanil + Cariprazine Majeure
- Amisulpride + Cariprazine Majeure
- Amobarbital + Cariprazine Majeure
- Apalutamide + Cariprazine Majeure
- Atazanavir + Cariprazine Majeure
- Benzhydrocodone / acetaminophen + Cariprazine Majeure
Autres interactions de Dabrafenib
- Abiraterone + Dabrafenib Majeure
- Apalutamide + Dabrafenib Majeure
- Carbamazepine + Dabrafenib Majeure
- Clarithromycin + Dabrafenib Majeure
- Dabrafenib + Deflazacort Majeure
- Dabrafenib + Desogestrel-ethinyl estradiol Majeure
Questions fréquentes
Can I take Cariprazine with Dabrafenib?
MediHelp rates the interaction as major. Cariprazine and Dabrafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib is a CYP3A4 inducer that may lower concentrations of cariprazine and its active metabolites, which are cleared by CYP3A4. The size of the effect is not well characterised, and loss of antipsychotic efficacy is possible.
How serious is the interaction between Cariprazine and Dabrafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as labeling advises against strong CYP3A4 inducers. If it is unavoidable, monitor for loss of psychiatric control and consider dose adjustment.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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