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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Dabrafenib + Deflazacort

Gravité: Majeure

Dabrafenib and Deflazacort: major interaction.

Dernière mise à jour

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Résumé

Dabrafenib induces CYP3A4 and can substantially reduce exposure to deflazacort's active metabolite. This may lead to loss of corticosteroid effect.

Ce que signifie cette interaction, en termes simples

Dabrafenib and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dabrafenib belongs to Oncology; Deflazacort belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Dabrafenib induces CYP3A4, accelerating clearance of deflazacort's active metabolite.

Conduite à tenir

Avoid the combination where possible, as deflazacort labeling advises against moderate or strong CYP3A4 inducers. If unavoidable, monitor for reduced efficacy and consider an alternative corticosteroid regimen.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dabrafenib with Deflazacort?

MediHelp rates the interaction as major. Dabrafenib and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib induces CYP3A4 and can substantially reduce exposure to deflazacort's active metabolite. This may lead to loss of corticosteroid effect.

How serious is the interaction between Dabrafenib and Deflazacort?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as deflazacort labeling advises against moderate or strong CYP3A4 inducers. If unavoidable, monitor for reduced efficacy and consider an alternative corticosteroid regimen.

What other medicines interact with Deflazacort?

MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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