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Interactions médicamenteuses

Clarithromycin + Erdafitinib

Gravité: Majeure

Clarithromycin and Erdafitinib: major interaction.

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Résumé

Strong CYP3A4 inhibitors increase erdafitinib exposure, raising the risk of adverse effects such as hyperphosphatemia, stomatitis and ocular toxicity.

Ce que signifie cette interaction, en termes simples

Clarithromycin and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clarithromycin belongs to Anti Bacterial; Erdafitinib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Clarithromycin inhibits CYP3A4, which contributes to erdafitinib metabolism along with CYP2C9.

Conduite à tenir

Use a non-CYP3A4-inhibiting antibiotic where possible. If unavoidable, monitor closely for erdafitinib toxicity and reduce the dose as needed, then reassess after clarithromycin is stopped.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clarithromycin with Erdafitinib?

MediHelp rates the interaction as major. Clarithromycin and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors increase erdafitinib exposure, raising the risk of adverse effects such as hyperphosphatemia, stomatitis and ocular toxicity.

How serious is the interaction between Clarithromycin and Erdafitinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-CYP3A4-inhibiting antibiotic where possible. If unavoidable, monitor closely for erdafitinib toxicity and reduce the dose as needed, then reassess after clarithromycin is stopped.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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