Interactions médicamenteuses
Dabigatran etexilate + Erdafitinib
Gravité: Majeure
Dabigatran etexilate and Erdafitinib: major interaction.
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Résumé
Erdafitinib inhibits P-glycoprotein and may increase the absorption of dabigatran, a P-gp substrate. Higher dabigatran concentrations raise the risk of bleeding, particularly with renal impairment.
Ce que signifie cette interaction, en termes simples
Dabigatran etexilate and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Erdafitinib belongs to Oncology.
Pourquoi elle survient
Inhibition of intestinal P-gp efflux by erdafitinib increases dabigatran bioavailability.
Conduite à tenir
If coadministration is unavoidable, take dabigatran at least 6 hours before or after erdafitinib and monitor for bleeding. Check renal function and consider a dabigatran dose reduction or alternative anticoagulant when renal function is impaired.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contre-indiquée
- Dabigatran etexilate + Ketorolac Contre-indiquée
- Dabigatran etexilate + Mifepristone Contre-indiquée
- Abciximab + Dabigatran etexilate Majeure
- Alteplase + Dabigatran etexilate Majeure
- Amiodarone + Dabigatran etexilate Majeure
Autres interactions de Erdafitinib
- Amobarbital + Erdafitinib Majeure
- Apalutamide + Erdafitinib Majeure
- Carbamazepine + Erdafitinib Majeure
- Chloramphenicol + Erdafitinib Majeure
- Clarithromycin + Erdafitinib Majeure
- Colchicine + Erdafitinib Majeure
Questions fréquentes
Can I take Dabigatran etexilate with Erdafitinib?
MediHelp rates the interaction as major. Dabigatran etexilate and Erdafitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erdafitinib inhibits P-glycoprotein and may increase the absorption of dabigatran, a P-gp substrate. Higher dabigatran concentrations raise the risk of bleeding, particularly with renal impairment.
How serious is the interaction between Dabigatran etexilate and Erdafitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is unavoidable, take dabigatran at least 6 hours before or after erdafitinib and monitor for bleeding. Check renal function and consider a dabigatran dose reduction or alternative anticoagulant when renal function is impaired.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
