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Interactions médicamenteuses

Clobazam + Levocetirizine

Gravité: Modérée

Clobazam and Levocetirizine: moderate interaction.

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Résumé

Clobazam is a benzodiazepine and levocetirizine can cause somnolence, so together they may increase sedation and impair psychomotor performance. Respiratory depression is unlikely at usual doses but additive drowsiness is expected.

Ce que signifie cette interaction, en termes simples

Clobazam and Levocetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Clobazam belongs to Central Nervous System; Levocetirizine belongs to Respiratory.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive CNS depression (pharmacodynamic).

Conduite à tenir

Monitor for excessive sedation and counsel on driving; consider a non-sedating alternative to the antihistamine if needed.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clobazam with Levocetirizine?

MediHelp rates the interaction as moderate. Clobazam and Levocetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine and levocetirizine can cause somnolence, so together they may increase sedation and impair psychomotor performance. Respiratory depression is unlikely at usual doses but additive drowsiness is expected.

How serious is the interaction between Clobazam and Levocetirizine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel on driving; consider a non-sedating alternative to the antihistamine if needed.

What other medicines interact with Levocetirizine?

MediHelp also lists interactions of Levocetirizine with, for example, Acrivastine, Asenapine transdermal, Avapritinib. The full list is on the Levocetirizine page.

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