Drug interactions
Clobazam + Levocetirizine
Severity: Moderate
Clobazam and Levocetirizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a benzodiazepine and levocetirizine can cause somnolence, so together they may increase sedation and impair psychomotor performance. Respiratory depression is unlikely at usual doses but additive drowsiness is expected.
What this interaction means in plain words
Clobazam and Levocetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Levocetirizine belongs to Respiratory.
Why it happens
Additive CNS depression (pharmacodynamic).
What to do
Monitor for excessive sedation and counsel on driving; consider a non-sedating alternative to the antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levocetirizine
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Levocetirizine?
MediHelp rates the interaction as moderate. Clobazam and Levocetirizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a benzodiazepine and levocetirizine can cause somnolence, so together they may increase sedation and impair psychomotor performance. Respiratory depression is unlikely at usual doses but additive drowsiness is expected.
How serious is the interaction between Clobazam and Levocetirizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel on driving; consider a non-sedating alternative to the antihistamine if needed.
What other medicines interact with Levocetirizine?
MediHelp also lists interactions of Levocetirizine with, for example, Acrivastine, Asenapine transdermal, Avapritinib. The full list is on the Levocetirizine page.
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