Interactions médicamenteuses
Clonidine + Guanfacine
Gravité: Majeure
Clonidine and Guanfacine: major interaction.
Dernière mise à jour
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Résumé
Both are central alpha-2 adrenergic agonists, so combining them duplicates therapy and increases the risk of hypotension, bradycardia and sedation. Patients with conduction disease may be at greater risk of heart block.
Ce que signifie cette interaction, en termes simples
Clonidine and Guanfacine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clonidine belongs to Cardiovascular; Guanfacine belongs to Cardiovascular.
Pourquoi elle survient
Additive central alpha-2 agonism reduces sympathetic outflow, causing pharmacodynamic synergism.
Conduite à tenir
Avoid using both together unless there is a clear indication; if used, monitor heart rate, blood pressure and sedation closely. Taper one agent gradually when stopping to avoid rebound hypertension.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Clonidine
- Acebutolol + Clonidine Majeure
- Amifostine + Clonidine Majeure
- Amiodarone + Clonidine Majeure
- Amoxapine + Clonidine Majeure
- Atenolol-chlorthalidone + Clonidine Majeure
- Atenolol + Clonidine Majeure
Autres interactions de Guanfacine
- Guanfacine + Lofexidine Majeure
- Aldesleukin + Guanfacine Modérée
- Amiodarone + Guanfacine Modérée
- Amisulpride + Guanfacine Modérée
- Amitriptyline + Guanfacine Modérée
- Amobarbital + Guanfacine Modérée
Questions fréquentes
Can I take Clonidine with Guanfacine?
MediHelp rates the interaction as major. Clonidine and Guanfacine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are central alpha-2 adrenergic agonists, so combining them duplicates therapy and increases the risk of hypotension, bradycardia and sedation. Patients with conduction disease may be at greater risk of heart block.
How serious is the interaction between Clonidine and Guanfacine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together unless there is a clear indication; if used, monitor heart rate, blood pressure and sedation closely. Taper one agent gradually when stopping to avoid rebound hypertension.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
