Interactions médicamenteuses
Apixaban + Clopidogrel
Gravité: Majeure
Apixaban and Clopidogrel: major interaction.
Dernière mise à jour
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Résumé
Adding clopidogrel to apixaban increases the risk of major and gastrointestinal bleeding compared with apixaban alone. The combination is sometimes needed, for example after stenting in patients with atrial fibrillation.
Ce que signifie cette interaction, en termes simples
Apixaban and Clopidogrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Clopidogrel belongs to Cardiovascular.
Pourquoi elle survient
Additive effects of P2Y12 platelet inhibition and factor Xa inhibition.
Conduite à tenir
Use only when there is a clear indication, keep the duration of dual therapy as short as possible, and consider a proton pump inhibitor. Monitor for bleeding and hemoglobin.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Apixaban
- Apixaban + Dabigatran Contre-indiquée
- Apixaban + Defibrotide Contre-indiquée
- Apixaban + Edoxaban Contre-indiquée
- Apixaban + Ketorolac Contre-indiquée
- Apixaban + Mifepristone Contre-indiquée
- Abciximab + Apixaban Majeure
Autres interactions de Clopidogrel
- Clopidogrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Abrocitinib + Clopidogrel Majeure
- Acetylsalicylic acid + Clopidogrel Majeure
- Aspirin + Clopidogrel Majeure
- Betrixaban + Clopidogrel Majeure
- Cangrelor + Clopidogrel Majeure
Questions fréquentes
Can I take Apixaban with Clopidogrel?
MediHelp rates the interaction as major. Apixaban and Clopidogrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adding clopidogrel to apixaban increases the risk of major and gastrointestinal bleeding compared with apixaban alone. The combination is sometimes needed, for example after stenting in patients with atrial fibrillation.
How serious is the interaction between Apixaban and Clopidogrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when there is a clear indication, keep the duration of dual therapy as short as possible, and consider a proton pump inhibitor. Monitor for bleeding and hemoglobin.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
