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Interactions médicamenteuses

Cobicistat + Paclitaxel

Gravité: Majeure

Cobicistat and Paclitaxel: major interaction.

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Résumé

Cobicistat is a strong CYP3A4 inhibitor and also inhibits P-gp, which may raise paclitaxel exposure. This can increase neutropenia and neuropathy.

Ce que signifie cette interaction, en termes simples

Cobicistat and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cobicistat belongs to Miscellaneous; Paclitaxel belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Inhibition of CYP3A4 and P-glycoprotein by cobicistat reduces paclitaxel clearance.

Conduite à tenir

Avoid the combination where an alternative antiretroviral is possible. If it is necessary, monitor blood counts and neuropathy closely and consider reducing the paclitaxel dose.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cobicistat with Paclitaxel?

MediHelp rates the interaction as major. Cobicistat and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a strong CYP3A4 inhibitor and also inhibits P-gp, which may raise paclitaxel exposure. This can increase neutropenia and neuropathy.

How serious is the interaction between Cobicistat and Paclitaxel?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative antiretroviral is possible. If it is necessary, monitor blood counts and neuropathy closely and consider reducing the paclitaxel dose.

What other medicines interact with Paclitaxel?

MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cyclosporine, Cyclosporin. The full list is on the Paclitaxel page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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