Interactions médicamenteuses
Cocaine + Phenelzine
Gravité: Contre-indiquée
Cocaine and Phenelzine: contraindicated interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, while phenelzine prevents breakdown of these amines. Together they can cause marked sympathetic stimulation with severe hypertension, hyperthermia, arrhythmias and serotonin toxicity. Topical cocaine has limited absorption but the combination is still labeled as contraindicated.
Ce que signifie cette interaction, en termes simples
Cocaine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cocaine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Pourquoi elle survient
Irreversible MAO inhibition plus monoamine reuptake blockade leads to excess synaptic catecholamines and serotonin.
Conduite à tenir
Avoid cocaine, including topical anesthetic use, in patients taking phenelzine or within 14 days of stopping it; choose a different local anesthetic. If exposure occurs, monitor blood pressure, heart rate and temperature and treat hypertensive crisis or serotonin toxicity urgently.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
Autres interactions de Phenelzine
- 5-HTP + Phenelzine Contre-indiquée
- Amitriptyline + Phenelzine Contre-indiquée
- Amoxapine + Phenelzine Contre-indiquée
- Atomoxetine + Phenelzine Contre-indiquée
- Benzphetamine + Phenelzine Contre-indiquée
- Brimonidine + Phenelzine Contre-indiquée
Autres interactions de Cocaine
- Cocaine + Isocarboxazid Contre-indiquée
- Cocaine + Procarbazine Contre-indiquée
- Amitriptyline + Cocaine Majeure
- Bisoprolol + Cocaine Majeure
- Citalopram + Cocaine Majeure
- Clomipramine + Cocaine Majeure
Questions fréquentes
Can I take Cocaine with Phenelzine?
MediHelp rates the interaction as contraindicated. Cocaine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, while phenelzine prevents breakdown of these amines. Together they can cause marked sympathetic stimulation with severe hypertension, hyperthermia, arrhythmias and serotonin toxicity. Topical cocaine has limited absorption but the combination is still labeled as contraindicated.
How serious is the interaction between Cocaine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including topical anesthetic use, in patients taking phenelzine or within 14 days of stopping it; choose a different local anesthetic. If exposure occurs, monitor blood pressure, heart rate and temperature and treat hypertensive crisis or serotonin toxicity urgently.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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