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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Citalopram + Cocaine

Gravité: Majeure

Citalopram and Cocaine: major interaction.

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Résumé

Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so combining it with an SSRI may increase serotonergic toxicity. Cocaine also has sympathomimetic and arrhythmogenic effects that may add to cardiac risk.

Ce que signifie cette interaction, en termes simples

Citalopram and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Citalopram belongs to Central Nervous System; Cocaine belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Additive serotonergic effects from monoamine reuptake inhibition, with added sympathomimetic and QT-related cardiac effects.

Conduite à tenir

Avoid concurrent use and counsel patients accordingly. Watch for features of serotonin toxicity and cardiovascular instability if exposure occurs.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Citalopram with Cocaine?

MediHelp rates the interaction as major. Citalopram and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so combining it with an SSRI may increase serotonergic toxicity. Cocaine also has sympathomimetic and arrhythmogenic effects that may add to cardiac risk.

How serious is the interaction between Citalopram and Cocaine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and counsel patients accordingly. Watch for features of serotonin toxicity and cardiovascular instability if exposure occurs.

What other medicines interact with Citalopram?

MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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