Interactions médicamenteuses
Amitriptyline + Cocaine
Gravité: Majeure
Amitriptyline and Cocaine: major interaction.
Dernière mise à jour
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Résumé
Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and tricyclics also block norepinephrine and serotonin reuptake. Combined use can cause exaggerated sympathomimetic effects, arrhythmias, hypertension and seizures. With topical cocaine, systemic absorption is usually small, but the effect can be significant with mucosal application at high doses or in abuse.
Ce que signifie cette interaction, en termes simples
Amitriptyline and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Cocaine belongs to Central Nervous System.
Pourquoi elle survient
Additive monoamine reuptake inhibition with potentiated adrenergic effects and additive proarrhythmic sodium channel blockade.
Conduite à tenir
Avoid cocaine, including recreational use, in patients taking amitriptyline. For medical topical use, use the lowest dose and monitor blood pressure, heart rhythm and ECG.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amitriptyline
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amitriptyline + Methylene blue Contre-indiquée
- Amitriptyline + Phenelzine Contre-indiquée
- Amitriptyline + Pimozide Contre-indiquée
- Amitriptyline + Procarbazine Contre-indiquée
- Amitriptyline + Safinamide Contre-indiquée
Autres interactions de Cocaine
- Cocaine + Isocarboxazid Contre-indiquée
- Cocaine + Phenelzine Contre-indiquée
- Cocaine + Procarbazine Contre-indiquée
- Bisoprolol + Cocaine Majeure
- Citalopram + Cocaine Majeure
- Clomipramine + Cocaine Majeure
Questions fréquentes
Can I take Amitriptyline with Cocaine?
MediHelp rates the interaction as major. Amitriptyline and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and tricyclics also block norepinephrine and serotonin reuptake. Combined use can cause exaggerated sympathomimetic effects, arrhythmias, hypertension and seizures. With topical cocaine, systemic absorption is usually small, but the effect can be significant with mucosal application at high doses or in abuse.
How serious is the interaction between Amitriptyline and Cocaine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including recreational use, in patients taking amitriptyline. For medical topical use, use the lowest dose and monitor blood pressure, heart rhythm and ECG.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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