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Interactions médicamenteuses

Codeine + Isocarboxazid

Gravité: Contre-indiquée

Codeine and Isocarboxazid: contraindicated interaction.

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Résumé

MAO inhibitors given with opioids have caused severe reactions including serotonin syndrome-like excitation, hypertension or hypotension, hyperpyrexia and coma. Codeine labeling advises against use during or shortly after MAOI therapy.

Ce que signifie cette interaction, en termes simples

Codeine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Codeine belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition increases monoamine levels and potentiates opioid effects, with an incompletely understood mechanism.

Conduite à tenir

Do not use codeine with isocarboxazid or within 14 days of stopping an MAOI. Choose a non-opioid or alternative analgesic.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Codeine with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Codeine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors given with opioids have caused severe reactions including serotonin syndrome-like excitation, hypertension or hypotension, hyperpyrexia and coma. Codeine labeling advises against use during or shortly after MAOI therapy.

How serious is the interaction between Codeine and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use codeine with isocarboxazid or within 14 days of stopping an MAOI. Choose a non-opioid or alternative analgesic.

What other medicines interact with Codeine?

MediHelp also lists interactions of Codeine with, for example, Alvimopan, Olanzapine / samidorphan, Phenelzine. The full list is on the Codeine page.

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