Interactions médicamenteuses
Conivaptan + Red yeast rice
Gravité: Majeure
Conivaptan and Red yeast rice: major interaction.
Dernière mise à jour
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Résumé
Red yeast rice supplies monacolin K, identical to lovastatin, which relies on CYP3A4 for clearance. Conivaptan is a potent CYP3A4 inhibitor, so monacolin K levels may rise and increase the risk of myopathy.
Ce que signifie cette interaction, en termes simples
Conivaptan and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Conivaptan inhibits CYP3A4, decreasing monacolin K metabolism.
Conduite à tenir
Avoid the combination and withhold red yeast rice during conivaptan therapy. Monitor for muscle symptoms and creatine kinase if exposure occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Red yeast rice
- Red yeast rice + Ritonavir Contre-indiquée
- Red yeast rice + Saquinavir Contre-indiquée
- Red yeast rice + Tipranavir Contre-indiquée
- Atazanavir + Red yeast rice Majeure
- Atorvastatin + Red yeast rice Majeure
- Cyclosporine + Red yeast rice Majeure
Questions fréquentes
Can I take Conivaptan with Red yeast rice?
MediHelp rates the interaction as major. Conivaptan and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Red yeast rice supplies monacolin K, identical to lovastatin, which relies on CYP3A4 for clearance. Conivaptan is a potent CYP3A4 inhibitor, so monacolin K levels may rise and increase the risk of myopathy.
How serious is the interaction between Conivaptan and Red yeast rice?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and withhold red yeast rice during conivaptan therapy. Monitor for muscle symptoms and creatine kinase if exposure occurs.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Tipranavir. The full list is on the Red yeast rice page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
