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Interactions médicamenteuses

Red yeast rice + Tipranavir

Gravité: Contre-indiquée

Red yeast rice and Tipranavir: contraindicated interaction.

Dernière mise à jour

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Résumé

Red yeast rice contains monacolin K, identical to lovastatin, a CYP3A4 substrate. Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and may substantially raise monacolin K levels, increasing the risk of muscle toxicity and rhabdomyolysis.

Ce que signifie cette interaction, en termes simples

Red yeast rice and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Red yeast rice belongs to Gastrointestinal Tract; Tipranavir belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Ritonavir-boosted tipranavir inhibits CYP3A4, increasing monacolin K (lovastatin) exposure.

Conduite à tenir

Avoid red yeast rice during tipranavir therapy. If a statin is needed, select one not reliant on CYP3A4 and monitor for muscle symptoms.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Red yeast rice with Tipranavir?

MediHelp rates the interaction as contraindicated. Red yeast rice and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Red yeast rice contains monacolin K, identical to lovastatin, a CYP3A4 substrate. Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and may substantially raise monacolin K levels, increasing the risk of muscle toxicity and rhabdomyolysis.

How serious is the interaction between Red yeast rice and Tipranavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid red yeast rice during tipranavir therapy. If a statin is needed, select one not reliant on CYP3A4 and monitor for muscle symptoms.

What other medicines interact with Red yeast rice?

MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Atazanavir. The full list is on the Red yeast rice page.

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