Interactions médicamenteuses
Red yeast rice + Saquinavir
Gravité: Contre-indiquée
Red yeast rice and Saquinavir: contraindicated interaction.
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Résumé
Red yeast rice contains monacolin K, identical to lovastatin, whose clearance depends on CYP3A4. Saquinavir, usually boosted with ritonavir, strongly inhibits CYP3A4 and can raise levels enough to cause myopathy or rhabdomyolysis.
Ce que signifie cette interaction, en termes simples
Red yeast rice and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Saquinavir (with ritonavir boosting) inhibits CYP3A4, increasing monacolin K (lovastatin) exposure.
Conduite à tenir
Avoid the combination and stop red yeast rice. Use a statin less dependent on CYP3A4 if lipid lowering is required.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Red yeast rice
- Red yeast rice + Ritonavir Contre-indiquée
- Red yeast rice + Tipranavir Contre-indiquée
- Atazanavir + Red yeast rice Majeure
- Atorvastatin + Red yeast rice Majeure
- Conivaptan + Red yeast rice Majeure
- Cyclosporine + Red yeast rice Majeure
Questions fréquentes
Can I take Red yeast rice with Saquinavir?
MediHelp rates the interaction as contraindicated. Red yeast rice and Saquinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Red yeast rice contains monacolin K, identical to lovastatin, whose clearance depends on CYP3A4. Saquinavir, usually boosted with ritonavir, strongly inhibits CYP3A4 and can raise levels enough to cause myopathy or rhabdomyolysis.
How serious is the interaction between Red yeast rice and Saquinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop red yeast rice. Use a statin less dependent on CYP3A4 if lipid lowering is required.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Tipranavir, Atazanavir. The full list is on the Red yeast rice page.
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