Interactions médicamenteuses
Cyclosporine + Red yeast rice
Gravité: Majeure
Cyclosporine and Red yeast rice: major interaction.
Dernière mise à jour
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Résumé
Monacolin K in red yeast rice is lovastatin, and cyclosporine markedly raises lovastatin exposure through CYP3A4 and OATP1B1 inhibition. This increases the risk of myopathy and rhabdomyolysis, particularly in transplant recipients.
Ce que signifie cette interaction, en termes simples
Cyclosporine and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Cyclosporine inhibits CYP3A4 and hepatic OATP uptake, increasing monacolin K (lovastatin) exposure.
Conduite à tenir
Avoid red yeast rice in patients on cyclosporine and treat dyslipidemia with a statin and dose appropriate for use with cyclosporine. Monitor for muscle symptoms and creatine kinase.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Red yeast rice
- Red yeast rice + Ritonavir Contre-indiquée
- Red yeast rice + Saquinavir Contre-indiquée
- Red yeast rice + Tipranavir Contre-indiquée
- Atazanavir + Red yeast rice Majeure
- Atorvastatin + Red yeast rice Majeure
- Conivaptan + Red yeast rice Majeure
Questions fréquentes
Can I take Cyclosporine with Red yeast rice?
MediHelp rates the interaction as major. Cyclosporine and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Monacolin K in red yeast rice is lovastatin, and cyclosporine markedly raises lovastatin exposure through CYP3A4 and OATP1B1 inhibition. This increases the risk of myopathy and rhabdomyolysis, particularly in transplant recipients.
How serious is the interaction between Cyclosporine and Red yeast rice?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid red yeast rice in patients on cyclosporine and treat dyslipidemia with a statin and dose appropriate for use with cyclosporine. Monitor for muscle symptoms and creatine kinase.
What other medicines interact with Red yeast rice?
MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Tipranavir. The full list is on the Red yeast rice page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
