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Interactions médicamenteuses

Crizotinib + Thioridazine

Gravité: Contre-indiquée

Crizotinib and Thioridazine: contraindicated interaction.

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Résumé

Thioridazine prolongs the QTc interval dose-dependently, and crizotinib lengthens the QTc interval, causes bradycardia and inhibits CYP3A4. Together they raise the risk of torsades de pointes and sudden cardiac death.

Ce que signifie cette interaction, en termes simples

Crizotinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Crizotinib belongs to Oncology; Thioridazine belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QTc prolongation; crizotinib adds bradycardia

Conduite à tenir

Do not co-administer; choose an alternative that does not prolong the QT interval.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Crizotinib with Thioridazine?

MediHelp rates the interaction as contraindicated. Crizotinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine prolongs the QTc interval dose-dependently, and crizotinib lengthens the QTc interval, causes bradycardia and inhibits CYP3A4. Together they raise the risk of torsades de pointes and sudden cardiac death.

How serious is the interaction between Crizotinib and Thioridazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an alternative that does not prolong the QT interval.

What other medicines interact with Thioridazine?

MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.

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