Interactions médicamenteuses
Crizotinib + Lonafarnib
Gravité: Contre-indiquée
Crizotinib and Lonafarnib: contraindicated interaction.
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Résumé
Lonafarnib is a sensitive CYP3A4 substrate, and crizotinib is a moderate CYP3A4 inhibitor, so lonafarnib exposure may increase considerably. This raises the risk of toxicity such as gastrointestinal effects, hepatotoxicity and QT prolongation.
Ce que signifie cette interaction, en termes simples
Crizotinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Crizotinib belongs to Oncology; Lonafarnib belongs to Miscellaneous.
Pourquoi elle survient
Crizotinib inhibits CYP3A4-mediated metabolism of lonafarnib.
Conduite à tenir
Avoid the combination in line with lonafarnib labeling for CYP3A inhibitors. If it cannot be avoided, a specialist should guide dose reduction and monitoring.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Crizotinib
- Crizotinib + Flibanserin Contre-indiquée
- Crizotinib + Lomitapide Contre-indiquée
- Crizotinib + Pimozide Contre-indiquée
- Crizotinib + Saquinavir Contre-indiquée
- Crizotinib + Thioridazine Contre-indiquée
- Adagrasib + Crizotinib Majeure
Autres interactions de Lonafarnib
- Alfuzosin + Lonafarnib Contre-indiquée
- Amobarbital + Lonafarnib Contre-indiquée
- Apalutamide + Lonafarnib Contre-indiquée
- Bosentan + Lonafarnib Contre-indiquée
- Carbamazepine + Lonafarnib Contre-indiquée
- Clarithromycin + Lonafarnib Contre-indiquée
Questions fréquentes
Can I take Crizotinib with Lonafarnib?
MediHelp rates the interaction as contraindicated. Crizotinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and crizotinib is a moderate CYP3A4 inhibitor, so lonafarnib exposure may increase considerably. This raises the risk of toxicity such as gastrointestinal effects, hepatotoxicity and QT prolongation.
How serious is the interaction between Crizotinib and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in line with lonafarnib labeling for CYP3A inhibitors. If it cannot be avoided, a specialist should guide dose reduction and monitoring.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Pimozide. The full list is on the Crizotinib page.
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